Please reply to the discussion post. There are two discussion post below. Please respond to each post with a minimum of ONE PARAGRAH FOR EACH POST
Please reply to the discussion post. There are two discussion post below. Please respond to each post with a minimum of ONE PARAGRAH FOR EACH POST
Mikayla Anoje
Cohort Study of Hypertension in HIV positive patients
COLLAPSE
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What study design was used?
The design of this study is a cohort design. As the methods section of the study states it is a prospective longitudinal study including HIV patients enrolled in the Kilombero and Ulanga Antiretroviral Cohort between the years 2013 and 2015. The goal of the study was to distinguish whether or not there is a connection between hypertension in HIV patients in rural Africa. Hypertension for this study is a systolic higher than 140 mmHg and or a diastolic greater than 90 mmHg.
How did the study design limit the findings of the article?
The study limited the age of the patients. I dont think that the findings were limited as we were looking at the prevalence of hypertension in HIV positive patients. When I think HIV I think sexually transmitted so starting the study at the age of 15 years old, when its likely that people would be sexually active. But also looking for hypertension in a generally healthy age group such as teenagers and early twenties adults would help to prove that there is a connection of hypertension in HIV positive patients.
Could a better study design be selected? Why or Why not?
For the goal of this specific study, I think the design and method used best suits it. In order to find whether or not HIV positive patients develop hypertension after being admitted into care would take time which is why the longitudinal study structure and multiple factors such as age, gender, BMI, smoking status, alcohol habits and more were utilized.
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Sheri Groves Wills
Dengue Fever
COLLAPSE
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What study design was used?
The disease I chose is Dengue and the article state, Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries (Song & Chung, 2010). The study design used for this study is prospective multi-centre observational study. This study aimed to enroll 7-8000 participants no younger than 5 years old that presented the febrile illness consistent with dengue to outpatient health facilities in 8 countries across Asia and Latin America. This study only took patients that presented 72 hours of fever on set and didnt present signs of severe disease. Because the range to measure the parameter of Dengue was asset daily for 6 days during the acute illness and it was ended with a follow up visit.
How did the study design limit the findings of the article?
This study design limits the finding due to the selection of the patient can be excluded due to their diagnosis and can be misdiagnosed because in the inclusion it requires no signs of severe disease. This study is coordinated by Tropical Medicine in Heidelberg, Germany, and the Oxford University Clinical Research Unit (OUCRU) in Ho Chi Minh City (HCMC), Vietnam and each has a different location conducting their own research sharing the data.
Could a better study design be selected? Why or Why not?
Given the case of this study done in 8 countries simultaneously it was expected to have proportional data, and a customized software was developed for this study in order to import all the information of this study. I would just stick to one demographic area because in the results they had a lot of negative diagnosis and in Vietnam for example 5% of the cases progressed to severe disease because I think focus in one demographic area will be more effective for the study.
References:
Jaenisch, T., Tam, D. T., Kieu, N. T., Van Ngoc, T., Nam, N. T., Van Kinh, N., Wills, B. (2016). Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries. BMC infectious diseases, 16, 120. doi:10.1186/s12879-016-1440-3
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